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Cyclosporine pharmacokinetics and dose monitoring after lung transplantation: Comparison between cystic fibrosis and other conditions

par Knoop, Christiane ;Vervier, Ingrid;Thiry, Philippe ;De Backer, Marc;Kovarik, John M.;Rousseau, Annick;Marquet, Pierre;Estenne, Marc
Référence Transplantation, 76, 4, page (683-688)
Publication Publié, 2003-08

Article révisé par les pairs

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Résumé :

In cystic fibrosis (CF), absorption of cyclosporine A (CsA) through the gastrointestinal tract is often impaired because of fat malabsorption. The aim of this study was to compare the steady-state pharmacokinetics of CsA and the inter- and intrasubject variability of CsA exposure in stable lung transplant recipients with and without CF and to determine the best single-time predictors of the area under the curve (AUC).