par Eeckman, Frédéric ;Moës, A.J.;Amighi, Karim
Référence International journal of pharmaceutics, 241, 1, page (113-125)
Publication Publié, 2002-07
Article révisé par les pairs
Résumé : The purpose of this work is to develop a new delivery concept making a thermosensitive polymer based on poly(N-isopropylacrylamide) (PNIPAAm) useful as a time-controlled drug release device, without any temperature changes of the dissolution medium. It was previously found that some salts induce a decrease of the polymer lower critical solution temperature (LCST). Use is here made of that property to show that salt concentration variations can be used as a substitute for temperature changes to make the polymer coating of compression-coated tablets soluble or insoluble, consequently creating a possible new concept of drug delivery control from delivery systems containing thermoresponsive polymers. The obtained results show the influence of the type and amount of salts incorporated into compression-coated tablets on the release lag time of a model drug. © 2002 Elsevier Science B.V. All rights reserved.