Molecular forms of the estrogen receptor in breast cancer

Leclercq, Guy

doi:doi/10.1016/S0960-0760(02)00026-2

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Molecular forms of the estrogen receptor in breast cancer

par Leclercq, Guy

Référence Journal of steroid biochemistry and molecular biology, 80, 3, page (259-272)
Publication Publié, 2002

Article révisé par les pairs

Résumé :

Estrogen receptors (ERs) of which two isoforms have been identified (α and β) are subjected to phosphorylation, glycozylation, ubiquitination and other post-transcriptional conformational changes giving rise to a very high molecular heterogeneity. Partial proteolysis of these receptors, as well as their high tendency to associate within oligomeric structures, reinforces this property. Investigations demonstrated that this heterogeneity is not a biochemical artefact suggesting some biological relevance. Our purpose was to review this topic, especially with regard to ERα from breast cancers. © 2002 Elsevier Science Ltd. All rights reserved.

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