par Winand, Jacques ;Dehaye, Jean-Paul ;Hebbelinck, Marcel ;Christophe, Jean
Référence Biochemical pharmacology, 26, 15, page (1429-1433)
Publication Publié, 1977
Article révisé par les pairs
Résumé : (1) Suloctidil (1-(4-isopropylthiophenyl)-2-n-octylamino-propanol) inhibited the in vitro lipolysis due to the action of isoproterenol, ACTH, and dibutyryl cAMP in rat epididymal adipose tissue fragments. Fifty per cent inhibition occurred at a 2 × 10-4M suloctidil concentration. The drug was not affecting cAMP and ATP levels. (2) Suloctidil inhibited non-competitively the hormonally stimulated activity of a crude preparation of triglyceride lipase, with a Kiapp of 2.5 × 10-4M. No effect was observed on lipoprotein lipase. (3) It is suggested that the antilipolytic action of the drug lies, at least partly, beyond the adenylate cyclase step, i.e. directly on the hormone sensitive triglyceride lipase. This effect is compared with that of nicotinic acid, clofibrate, procaine, and β-adrenergic blocking. © 1977.