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Does disseminated intravascular coagulation lead to multiple organ failure?

par Vincent, Jean Louis ;De Backer, Daniel
Référence Critical care clinics, 21, 3 SPEC. ISS., page (469-477)
Publication Publié, 2005-07

Article révisé par les pairs

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Résumé :

The mechanisms that underlie the microvascular dysfunction that occurs in sepsis are still uncertain, but various contributing factors have been identified that likely act in combination and in varying degrees to create the final picture of a severely impaired regional oxygen transport and use. Teasing out the mechanisms whereby tissue hypoxia leads to the interlocking coagulation, metabolic, hormonal, and immunologic derangements seen in severe sepsis and MOF is the key to understanding these complex processes and to determining how best to manage patients with this condition. With newer techniques to visualize the microcirculation, there should soon be answers to some of the many questions that remain regarding the mechanisms underlying tissue hypoxia and its links to MOF. © 2005 Elsevier Inc. All rights reserved.