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Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.

par Huart, Pascal ;Brasseur, Robert ;Goormaghtigh, Erik ;Ruysschaert, Jean Marie
Référence Biochimica et biophysica acta, 799, 2, page (199-202)
Publication Publié, 1984-06

Article révisé par les pairs

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Résumé :

We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.