par Ligot, Noemie 
;Krystkowiak, Pierre;Simonin, Clémence;Goldman, Serge ;Peigneux, Philippe ;Van Naemen, John ;Monclus, Michel ;Lacroix, Simon Frédéric;Devos, David;Dujardin, Kathy;Delmaire, Christine;Bardinet, Eric;Delval, Arnaud;Delliaux, Marie;Defebvre, Luc;Yelnik, Jerome;Blond, Serge;Destée, Alain;De Tiege, Xavier
Référence Journal of cerebral blood flow and metabolism, 31, 1, page (41-46)
Publication Publié, 2011-01
;Krystkowiak, Pierre;Simonin, Clémence;Goldman, Serge ;Peigneux, Philippe ;Van Naemen, John ;Monclus, Michel ;Lacroix, Simon Frédéric;Devos, David;Dujardin, Kathy;Delmaire, Christine;Bardinet, Eric;Delval, Arnaud;Delliaux, Marie;Defebvre, Luc;Yelnik, Jerome;Blond, Serge;Destée, Alain;De Tiege, Xavier Référence Journal of cerebral blood flow and metabolism, 31, 1, page (41-46)
Publication Publié, 2011-01
Article révisé par les pairs
| Résumé : | Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model. |
