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Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.

par Manciu, Liliane ;Chang, XB.;Riordan, John R;Buyse, Frédéric ;Ruysschaert, Jean Marie
Référence FEBS letters, 493, 1, page (31-35)
Publication Publié, 2001-03

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Titre:	Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.
Auteur:	Manciu, Liliane; Chang, XB.; Riordan, John R; Buyse, Frédéric; Ruysschaert, Jean Marie
Informations sur la publication:	FEBS letters, 493, 1, page (31-35)
Statut de publication:	Publié, 2001-03
Sujet CREF:	Chimie
MeSH keywords:	ATP-Binding Cassette Transporters -- chemistry
	ATP-Binding Cassette Transporters -- metabolism
	Acrylamide -- pharmacology
	Adenosine Triphosphatases -- metabolism
	Antibiotics, Antineoplastic -- pharmacology
	Antineoplastic Agents -- pharmacology
	Binding Sites
	Biological Transport
	Catalytic Domain
	Cell Line
	Cell Membrane -- metabolism
	Daunorubicin -- pharmacology
	Dose-Response Relationship, Drug
	Doxorubicin -- pharmacology
	Drug Resistance, Neoplasm
	Flow Cytometry
	Humans
	Kinetics
	Models, Chemical
	Multidrug Resistance-Associated Proteins
	Protein Binding
	Protein Conformation -- drug effects
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0014-5793
	info:pii/S0014579301022700
	info:pmid/11278000