par Antoine, Marie-Hélène
;Herchuelz, André
;Lebrun, Philippe 
Référence Pharmacology, 44, 2, page (101-106)
Publication Publié, 1992



Référence Pharmacology, 44, 2, page (101-106)
Publication Publié, 1992
Article révisé par les pairs
Résumé : | Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidil was not impaired in the absence of extracellular Ca2+ but was completely abolished by glibenclamide. These observations are compatible with the involvement of a metabolic process in the control of the K+ permeability, namely with the existence in rat portal veins of ATP-sensitive K+ channels. |