par Khelili, Smail;Lebrun, Philippe
;de Tullio, Pascal;Pirotte, Bernard
Référence Bioorganic & medicinal chemistry, 14, 10, page (3530-3534)
Publication Publié, 2006-05

Référence Bioorganic & medicinal chemistry, 14, 10, page (3530-3534)
Publication Publié, 2006-05
Article révisé par les pairs
Résumé : | Some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas were prepared and evaluated as putative potassium channel openers on the vascular and uterine smooth muscle tissue (myorelaxant effect), as well as on insulin-secreting pancreatic islets (inhibition of insulin release). The pharmacological results indicated that these compounds exhibited a marked biological activity on these three tissues. |