Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.

Khelili, Smail; Lebrun, Philippe; de Tullio, Pascal; Pirotte, Bernard

doi:doi/10.1016/j.bmc.2006.01.009

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Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.

par Khelili, Smail ;Lebrun, Philippe

;de Tullio, Pascal ;Pirotte, Bernard
Référence Bioorganic & medicinal chemistry, 14, 10, page (3530-3534)
Publication Publié, 2006-05

Article révisé par les pairs

Résumé :

Some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas were prepared and evaluated as putative potassium channel openers on the vascular and uterine smooth muscle tissue (myorelaxant effect), as well as on insulin-secreting pancreatic islets (inhibition of insulin release). The pharmacological results indicated that these compounds exhibited a marked biological activity on these three tissues.

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