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N-(Phosphonacetyl)-L-aspartate (PALA): current status.

par Rozencweig, Marcel ;Abele, R;Piccart-Gebhart, Martine ;Von Hoff, D D;Muggia, F
Référence Recent Results in Cancer Research, 74, page (72-77)
Publication Publié, 1980

Article révisé par les pairs

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Résumé :

N-(Phosphonoacetyl)-L-aspartate (PALA) is a synthetic antimetabolite exhibiting striking oncolytic properties against a wide variety of experimental solid tumors. The clinical dose-limiting factor is mucocutaneous toxicity which is reversible and dose-related. Delineation of the single-agent activity of PALA in human cancer must still await results of recently activated trials.