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Megakaryoblastic leukemia with an N-ras mutation and late acquisition of a Philadelphia chromosome.

par Vandenberghe, E;Martiat, Philippe ;Baens, M;Stul, Michel;Ferrant, Augustin;Cuneo, A;Cassiman, J.-J.;Mecucci, C;Van den Berghe, Herman
Référence Leukemia, 5, 8, page (683-686)
Publication Publié, 1991-08

Article révisé par les pairs

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Résumé :

A patient is described with de novo acute non-lymphocytic leukemia of megakaryoblastic lineage with tri-lineage myelodysplasia. This patient was studied cytogenetically and using molecular genetic techniques throughout her clinical course. She had an N-ras mutation at diagnosis which persisted despite a bone marrow transplant, and acquired a Philadelphia chromosome associated with a P190 BCR-ABL transcript at clinical relapse 3 months post-transplantation.