Résumé : Replacement of acetate by bicarbonate in dialysate has been proposed to reduce morbidity during hemodialysis sessions with large-area artificial kidneys. The routine use of such a dialysate raises numerous technical problems which have already been discussed by Sargent et al: (1) accuracy of proportioning of bicarbonate dialysate to achieve a controlled bicarbonate concentration coupled with the monitoring of multiple-stream system; relative insolubility of bicarbonate; (3) stability of concentrated sodium bicarbonate; (4) bacteriostatic properties of these solutions. These problems were solved in an individual three-component dialysate system (Drake-Willok 4015) but although this procedure could theoretically be conversed to a central delivery system, bicarbonate dialysate has not been routinely used in this application since stability of such a dialysate in tanks and long tubings have to be assessed. A system is described in which these problems are solved and which is able to automatically produce bicarbonate dialysate on a large scale, i.e. for 30 simultaneous dialyses.