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Reduced cholecystokinin immunoreactivity in the cerebrospinal fluid of patients with psychiatric disorders.

par Verbanck, Paul ;Lotstra, Françoise ;Gilles, Christian;Linkowski, Paul ;Mendlewicz, Julien ;Vanderhaeghen, Jean-Jacques
Référence Life sciences, 34, 1, page (67-72)
Publication Publié, 1984-01

Article révisé par les pairs

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Résumé :

The close relationship of cholecystokinin peptides with some of the dopamine pathways and the limbic system suggests a putative role for these peptides in the pathophysiology of neuropsychiatric disorders such as Parkinson's disease, manic-depression and schizophrenia. By use of radioimmunoassay, we report a significant decrease in cholecystokinin-immunoreactivity in the cerebrospinal fluid of patients with bipolar manic-depression and untreated schizophrenia in comparison to control subjects.