par Vanhamme, Luc ;Pays, Etienne
Référence Molecular and biochemical parasitology, 91, 1, page (107-116)
Publication Publié, 1998-03
Article révisé par les pairs
Résumé : We present an overview of the regulation of vsg expression, focusing on initiation and elongation of transcription as well as processing and stabilization of the transcripts. We propose a model where common factors are involved in the reverse controls of the genes for the two main stage-specific antigens, the Vsg and procyclin: a cross-talk between the two transcription units would allow a fast rerouting of limiting factors at differentiation, thereby allowing the expression of only one type of antigen at a time. A similar mechanism would ensure that only one vsg ES is fully expressed at a time in bloodstream forms.