• Citer

Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist.

par Van Reeth, Olivier ;Olivares Fontt, Elizabeth ;Turek, F.W.;Granjon, L;Mocaer, Elisabeth
Référence NeuroReport, 9, 8, page (1901-1905)
Publication Publié, 1998-06

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Using 'jet lag' paradigms involving phase shifts in the light-dark (LD) cycle, we studied the effects of S-20098 on the circadian clock of a diurnal rodent. Arvicanthis mordax, entrained to a regular LD cycle, were subjected to advance shifts (i.e. 4, 6 or 8 h) in the LD cycle and injected with vehicle or the melatonin agonist S-20098 (20 mg/kg) the day of the shift (and also on subsequent days in the 6 h or 8 h shift paradigms). In each condition, S-20098 accelerated by about 30% resynchronization to the new LD cycle. These data, which are the first to demonstrate the chronobiotic effects of a melatonin agonist in a diurnal rodent, provide new insights for the design of human chronopharmacological protocols.