• Citer

Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.

par Dombrowicz, D.;Lin, S;Flamand, Véronique ;Brini, A T;Koller, B H;Kinet, J P
Référence Immunity, 8, 4, page (517-529)
Publication Publié, 1998-04

Article révisé par les pairs

• Détails
• Contenu

Résumé :

A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.