par De Pauw, Luc 
;Abramowicz, Daniel ;Donckier De Donceel, Vincent ;Kornreich, Anne ;Destrée, M.;Demoor, François-Xavier ;Andrien, Marc ;Lambermont, Micheline ;Goldman, Michel
Référence Nephrology, dialysis, transplantation, 13, 1, page (34-36)
Publication Publié, 1998-01
;Abramowicz, Daniel ;Donckier De Donceel, Vincent ;Kornreich, Anne ;Destrée, M.;Demoor, François-Xavier ;Andrien, Marc ;Lambermont, Micheline ;Goldman, Michel Référence Nephrology, dialysis, transplantation, 13, 1, page (34-36)
Publication Publié, 1998-01
Article révisé par les pairs
| Résumé : | BACKGROUND: Infusion of donor bone marrow cells induces tolerance in allograft models. CD34+ stem cells present in human bone marrow could be endowed with tolerogenic properties. METHODS: CD34+ stem cells were isolated from bone marrow extracted from vertebral bodies of cadaveric donors. Donor CD34+ cells (0.6-3.7 x 10(6)/kg) were infused during surgery in 10 kidney transplant recipients receiving OKT3 as induction therapy. Chimerism was investigated using nested PCR for donor-specific HLA alleles. RESULTS: The infusion of CD34+ stem cells was perfectly tolerated. Five patients remained free of acute rejection at follow-up, 47-325 days post-operatively. The five other patients underwent a single episode of corticosensitive acute rejection. Long-term chimerism was not induced in the seven patients investigated for the persistence of donor DNA. CONCLUSIONS: Infusion of donor CD34+ stem cells in kidney transplantation is safe. The clinical usefulness of the procedure remains to be established. |
