par Ladrière, Laurence 
;Malaisse Lagae, Francine ;Fuhlendorff, J;Malaisse, Willy
Référence Research communications in molecular pathology and pharmacology, 97, 1, page (53-59)
Publication Publié, 1997-07
;Malaisse Lagae, Francine ;Fuhlendorff, J;Malaisse, Willy Référence Research communications in molecular pathology and pharmacology, 97, 1, page (53-59)
Publication Publié, 1997-07
Article révisé par les pairs
| Résumé : | The hypoglycemic agents, glibenclamide and repaglinide, when administered intragastrically to overnight fasted hereditarily diabetic animals, were found to oppose the rise in the plasma insulin/glucose ratio otherwise evoked by refeeding of the GK rats. Such was not the case after oral administration of glimepiride, despite the fact that this sulfonylurea minimized the rise in glycemia associated with refeeding. The altered restoration of a high insulin/glucose ratio in GK rats that received glibenclamide or repaglinide before refeeding suggests that these long-acting hypoglycemic agents may delay the refeeding-induced relief of the B-cell from the fasting-associated refractoriness to glucose. |
