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Modulation of the growth of hematopoietic human stem cells by growth factors: comparison of umbilical cord blood with bone marrow

par De Bruyn, Cécile ;Stryckmans, Pierre ;Bron, Dominique ;Ley, P.;Degueldre, Michel ;Delforge, Alain
Référence Journal of hematotherapy, 2, 2, page (241-242)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

The growth of cord blood and bone marrow myeloid mononuclear cells in response to single and multiple growth factors has been examined. Single factors such as IL-3, IL-6, GM-CSF, and stem cell factor did not optimally stimulate growth of cord blood CFU-GM. However a synergistic stimulation was observed when the factors were combined. This effect was seen in both the presence and absence of added fetal calf serum.