What clinicians need to know about antioestrogen resistance in breast cancer therapy.

Milano, Amalia; Dal Lago, Lissandra; Sotiriou, Christos; Piccart-Gebhart, Martine; Cardoso, Fatima

doi:doi/10.1016/j.ejca.2006.06.022

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What clinicians need to know about antioestrogen resistance in breast cancer therapy.

par Milano, Amalia ;Dal Lago, Lissandra

;Sotiriou, Christos

;Piccart-Gebhart, Martine

;Cardoso, Fatima

Référence European journal of cancer, 42, 16, page (2692-2705)
Publication Publié, 2006-11

Article révisé par les pairs

Résumé :

Tamoxifen is the drug most used for early breast cancer treatment in oestrogen receptor (ER) positive patients. Unfortunately, despite high ER tumour levels in a tumour, resistance to endocrine therapy, either de novo or acquired after prolonged treatment, can occur. In this review, we will try to summarise the postulated mechanisms of hormonal-resistance, namely, the role of co-regulators and the crosstalk between the HER-2, IGF-IR, Cox-2 and ER pathways. Other predictive markers of tamoxifen-resistance/response, such as cyclin E and UPA/PAI-1, are also discussed.

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