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Experimental analysis of radiation dose distribution in radiosurgery. II. Dose fall-off outside the target volume.

par Massager, Nicolas ;Maris, Calliope ;Nissim, Ouzi;Devriendt, Daniel ;Salmon, Isabelle ;Levivier, Marc
Référence Stereotactic and functional neurosurgery, 87, 3, page (137-142)
Publication Publié, 2009

Article révisé par les pairs

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Résumé :

INTRODUCTION: The role of radiation dose delivered to surrounding tissues outside target is often minimized in radiosurgery. We study histopathological effects of dose fall-offs outside the target using an experimental model of trigeminal nerve irradiation in the rat. MATERIAL AND METHODS: Sixteen rats were irradiated with a Gamma Knife at the right trigeminal nerve using a 90-Gy dose and 4 different gradients of dose fall-off; the brainstem at the trigeminal nerve root entry was histologically analyzed 3 months after irradiation. RESULTS: Four specific histopathological reactions were found as a consequence of the irradiation. All these reactions were significantly related to the gradient of dose fall-off. CONCLUSIONS: Different dose distributions outside the target could produce various histological effects in the irradiated tissue that could influence the outcome of radiosurgical treatment. A more rapid fall-off of dose (higher selectivity) is associated with less risk of histological changes in tissues surrounding the target.