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Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice.

par El Yacoubi, Malika;Ledent, Catherine ;Parmentier, Marc ;Costentin, Jean;Vaugeois, Jean-Marie
Référence European journal of pharmacology, 519, 3, page (290-291)
Publication Publié, 2005-09

Article révisé par les pairs

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Résumé :

Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.