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Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.

par Delfourne, Evelyne;Kiss, Robert ;Le Corre, Laurent;Dujols, Frederic;Bastide, Jean;Collignon, Françoise;Lesur, Brigitte;Frydman, Armand;Darro, Francis
Référence Bioorganic & medicinal chemistry, 12, 15, page (3987-3994)
Publication Publié, 2004-08

Article révisé par les pairs

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Résumé :

A series of cycle C and D-substituted phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin have been synthesized on the basis of Diels-Alder reactions involving quinoline-5,8-dione and 2- (or un)-substituted-N,N-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order.