Titre:
  • Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
Auteur:Delfourne, Evelyne; Kiss, Robert; Le Corre, Laurent; Dujols, Frederic; Bastide, Jean; Collignon, Françoise; Lesur, Brigitte; Frydman, Armand; Darro, Francis
Informations sur la publication:Bioorganic & medicinal chemistry, 12, 15, page (3987-3994)
Statut de publication:Publié, 2004-08
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Ascididemin
Marine alkaloids
Meridine
Pyridoacridine
MeSH keywords:Acridines -- chemistry
Alkaloids -- chemical synthesis
Alkaloids -- pharmacology
Antineoplastic Agents -- chemical synthesis
Antineoplastic Agents -- pharmacology
Cell Division -- drug effects
Cell Line, Tumor
Drug Design
Drug Screening Assays, Antitumor
Heterocyclic Compounds with 4 or More Rings -- chemical synthesis
Heterocyclic Compounds with 4 or More Rings -- pharmacology
Humans
Molecular Structure
Phenanthrolines -- chemical synthesis
Phenanthrolines -- chemistry
Phenanthrolines -- pharmacology
Quinolines -- pharmacology
Structure-Activity Relationship
Note générale:Journal Article
Langue:Anglais
Identificateurs:urn:issn:0968-0896
info:doi/10.1016/j.bmc.2004.06.006
info:pii/S0968089604004225
info:scp/3042793405
info:pmid/15246075