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SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF.

par Xie, Jingwei ;Vandenbroere, Isabelle ;Pirson, Isabelle
Référence FEBS letters, 582, 20, page (3011-3017)
Publication Publié, 2008-09

Article révisé par les pairs

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Résumé :

We identified intersectin1 (ITSN1) as a new binding partner of the SH2 domain containing inositol 5-phosphatase 2 (SHIP2). The interaction between SHIP2 and ITSN1 was confirmed in vivo. Src homology 3D, A, C, and E domains of ITSN1 were shown to be implicated in the interaction. In response to epidermal growth factor, SHIP2 expression could recruit the ITSN1 short form (ITSN1-S) to the cell membrane, while SHIP2 overexpression did not modulate the ITSN-mediated extracellular signal-regulated kinase1/2 and c-Jun NH2-terminal kinase activation. Our data provide a molecular link between SHIP2 and ITSN1 which are involved in receptor endocytosis regulation.