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The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells.

par Mijatovic, Tatjana ;Jungwirth, Ute;Heffeter, Petra;Hoda, Mir Ali Reza;Dornetshuber, Rita;Kiss, Robert ;Berger, Walter
Référence Cancer letters, 282, 1, page (30-34)
Publication Publié, 2009-09

Article révisé par les pairs

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Résumé :

We recently reported that over-expressed Na(+)/K(+)-ATPase alpha subunits are new important anti-cancer targets. Cardiotonic steroids are the natural ligands of Na(+)/K(+)-ATPase and thus potentially potent anti-cancer agents with a novel mechanism of action. We report here that the hemi-synthetic cardenolide 19-hydroxy-2''oxovoruscharin is impressively active in cancer cells expressing diverse forms of multi-drug resistance (MDR) either conferred by the over-expression of selected drug-transporter proteins or induced by a range of chemotherapeutic agents. Together with the inability of tumor cells to acquire resistance to 19-hydroxy-2''oxovoruscharin, our data suggest that this novel compound could be especially applicable to notoriously drug-resistant cancers.