par Le Moine, Alain ;Goldman, Michel
Référence American Journal of Transplantation, 3, 2, page (101-106)
Publication Publié, 2003-02
Article révisé par les pairs
Résumé : Allograft rejection results from separate pathways primarily controlled by CD4+ T cells. Refinement of transplantation models together with investigations on rejection occurring despite co-stimulation blockade revealed unexpected pathways involving CD8+ T cells, NK cells and Th2 cytokines. In this minireview, we discuss these non-classical pathways of allograft rejection and their relevance for the induction of tolerance in the clinics.