par Dirix, Violette 
;Verscheure, Virginie ;Goetghebuer, T;Hainaut, Marc;Debrie, Anne-Sophie;Locht, Camille ;Mascart, Françoise
Référence Clinical and vaccine immunology, 16, 12, page (1816-1821)
Publication Publié, 2009-12
;Verscheure, Virginie ;Goetghebuer, T;Hainaut, Marc;Debrie, Anne-Sophie;Locht, Camille ;Mascart, Françoise Référence Clinical and vaccine immunology, 16, 12, page (1816-1821)
Publication Publié, 2009-12
Article révisé par les pairs
| Résumé : | Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion. |
