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Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses.

par Mascart, Françoise ;Verscheure, Virginie ;Malfroot, Anne;Hainaut, Marc;Pierard, Denis;Temerman, Stéphane;Peltier, Alexandra;Debrie, Anne-Sophie;Levy, Jack ;Del Giudice, Guiseppe;Locht, Camille
Référence The Journal of immunology, 170, 3, page (1504-1509)
Publication Publié, 2003-02

Article révisé par les pairs

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Résumé :

Neonatal immaturity of the immune system is currently believed to generally limit the induction of immune responses to vaccine Ags and to skew them toward type 2 responses. We demonstrated here that Bordetella pertussis infection in very young infants (median, 2 mo old) as well as the first administration of whole-cell pertussis vaccine induces B. pertussis Ag-specific IFN-gamma secretion by the PBMC of these infants. IFN-gamma was secreted by both CD4(+) and CD8(+) T lymphocytes, and the levels of Ag-induced IFN-gamma secretion did not correlate with the age of the infants. Appearance of the specific Th-1 cell-mediated immunity was accompanied by a general shift of the cytokine secretion profile of these infants toward a stronger Th1 profile, as evidenced by the response to a polyclonal stimulation. We conclude that the immune system of 2-mo-old infants is developmentally mature enough to develop Th1 responses in vivo upon infection by B. pertussis or vaccination with whole-cell pertussis vaccines.