par Chamekh, Mostafa 
Référence Journal of Biomedicine and Biotechnology (Print), 2007, 3, page (59430)
Publication Publié, 2007

Référence Journal of Biomedicine and Biotechnology (Print), 2007, 3, page (59430)
Publication Publié, 2007
Article révisé par les pairs
Résumé : | Activation of the immune system against protozoan infections relies particularly on two specific signals provided by cognate interaction of T cells with antigen presenting cells (APCs). The first signal is attributed to binding of the T-cell receptor (TCR) to peptide/MHC complexes on the surface of APCs, whereas the second signal is triggered through binding of several costimulatory molecules on the surface of APCs with their corresponding receptors on T cells. Among these costimulatory signallings, CD40/CD40L interactions have been particularly investigated in protozoan infection models with regard to their potential to amplify cell-mediated immunity against intracellular parasites. This article reviews current studies of the potential role of CD40/CD40L interaction in the modulation of immune responses against some protozoan parasites and highlights recent developments regarding manipulation of this interaction for promoting control of parasite infections. |