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Molecular mechanisms of extracellular adenine nucleotides-mediated inhibition of human Cd4(+) T lymphocytes activation.

par Duhant, Xavier ;Suarez Gonzalez, Nathalie ;Schandené, Liliane ;Goldman, Michel ;Communi, Didier ;Boeynaems, Jean-Marie
Référence Purinergic Signalling, 1, 4, page (377-381)
Publication Publié, 2005-12

Article révisé par les pairs

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Résumé :

We have previously reported that ATPgammaS, a slowly hydrolyzed analog of ATP, inhibits the activation of human CD4(+) T lymphocytes by anti-CD3 and anti-CD28 mAb. In this report we have partially characterized the signaling mechanisms involved in this immunosuppressive effect. ATPgammaS had no inhibitory effect on CD4(+) T-cell activation induced by PMA and anti-CD28, indicating that it acts proximally to the TCR. It had no effect on the calcium rise induced by CD3/CD28 stimulation, but inhibited the phosphorylation of three kinases, ERK2, p38 MAPK and PKB, that play a key role in the activation of T cells. The receptor involved in these actions remains unidentified.