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Copper-Catalyzed, Photoinduced Carbonylative Cross-Coupling of Alkyl Iodides with Amines, Alcohols and Sodium Hydroxide

par Adaoudi, Omaima ;Le Bescont, Julie ;Bruneau-Voisine, Antoine;Le Flohic, Alexandre;Evano, Gwilherm
Référence Organic letters, 28
Publication Publié, 2026-08-13

Article révisé par les pairs

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Résumé :

A general photoinduced copper-catalyzed carbonylative cross-coupling of alkyl iodides with amines for the synthesis of amides under mild conditions is reported. Using a readily accessible, inexpensive copper complex, [Cu(bcp)DPEphos]PF6, the reaction proceeds at room temperature and accommodates a broad range of amines. Notably, the transformation can also be performed under ambient carbon monoxide pressure and can be extended to hydrazines, alcohols, and sodium hydroxide.