• Citer

Amine-Functionalized POEGMA Thermogels: Thermoresponsive Behavior, Crosslinking and Additive Manufacturing

par Lipowska-Kur, Daria;Otulakowski, Lukasz;Grochowska, Pawel;Siminska-Stanny, Julia ;Filipek, Katarzyna;Sieron, Lukasz;Jelonek, Katarzyna;Shavandi, Armin ;Utrata-Wesolek, Katarzyna
Référence Young European Scientists
Publication Publié, 2026-06-15

Abstract de conférence

• Détails
• Contenu

Résumé :

Oligo(ethylene glycol) methacrylate-based polymers, owing to their non-immunogenicity, non-toxicity, ease of synthesis via advanced polymerization techniques (e.g. RAFT) and tunable physicochemical properties, have gained interest as thermoresponsive biomaterials[1,2,3], making them candidates for thermogels applied in biomedical applications.This work investigates the thermogelation behavior of high-molar-mass copolymers of oligo(ethylene glycol) methacrylate (Mn = 300 g/mol), di(ethylene glycol) methacrylate and 2-aminoethyl methacrylate hydrochloride in ammonium and amine forms with various polymer architectures. Ammonium and amine groups were found to play a key role in regulating thermogelation and network stability. Depending on polymer architecture, ionization state and medium (water or PBS), reversible thermogel formation occurred over a broad temperature range (25–70 °C). In diblock copolymers, amine groups further enabled chemical crosslinking with poly(ethylene glycol) diacrylate and N,N′-methylenebisacrylamide via photo-induced radical and nucleophilic addition reactions, enhancing thermogel stability. Rheological studies revealed shear-thinning behavior, suitable viscoelasticity and rapid structural recovery, supporting extrusion-based 3D printing and volumetric additive manufacturing, demonstrating versatility across different printing platforms. The printed constructs exhibited temperature-responsive swelling behavior, highlighting their potential for 4D printing applications. Finally, in vitro studies confirmed good cytocompatibility toward skin cells, with cell viability maintained within the hydrogel matrix.References:[1]. A. Ramírez-Jiménez, K.A. Montoya-Villegas, A. Licea-Claverie, M.A. Gónzalez-Ayón, Polymers (Basel), 2019, 11, https://doi.org/10.3390/polym11101657.[2]. Y. Yuan, K. Raheja, N.B. Milbrandt, et al. RSC Appl. Polym. 2023, 1, 158–189[3]. A. Singh, N. Dowdall, T. Hoare, Biomacromolecules, 2025, 26, 3929–3973. https://doi.org/10.1021/acs.biomac.5c00145.