par Heymans, Thibault 
;Durand-Baudet, Loïc ;Landrain, Yohann ;Evano, Gwilherm
Référence Organic letters, 28
Publication A Paraître, 2026-06-05
;Durand-Baudet, Loïc ;Landrain, Yohann ;Evano, Gwilherm Référence Organic letters, 28
Publication A Paraître, 2026-06-05
Article révisé par les pairs
| Résumé : | A general and efficient strategy for the synthesis of maleimides from readily accessible ynamides and α-ketoesters via in situ generat-ed lithiated ketenimines, engaging in a cascade sequence involving formal anionic (2+2) cycloaddition, cycloreversion, and cy-clocondensation, is reported. This method enables rapid access to a wide range of densely functionalized maleimides with excellent functional group tolerance, under conditions allowing either retention or removal of the N protecting group. The resulting scaffolds can be readily diversified, notably through a “nitrogen switch” strategy to access distinct heterocycles. The power of this approach is demonstrated in the concise syntheses of denigrin A and aqabamycin A, as well as the first unified and divergent synthesis of an-trodins A-C, highlighting its potential as a versatile platform for the rapid construction of functional maleimide architectures. |
