Article révisé par les pairs
Résumé : Nonlupus full-house nephropathy (NL-FHN) is a distinct clinicopathological entity defined as the concurrent positive staining for immunoglobulin A, immunoglobulin G, immunoglobulin M, C3, and C1q at immunofluorescence or immunohistochemistry on kidney biopsy samples with lupus nephritis light microscopy lesions without clinical and laboratory features of systemic lupus erythematosus. Secondary forms of NL-FHN are mainly infectious in ∼40% of cases (human immunodeficiency virus and Bartonella being the leading infectious causes). Autoimmune diseases represent less than 20% of secondary NL-FHNs. The renal prognosis is usually poor because NL-FHN has been reported as an independent risk factor for end-stage renal disease in clinical studies. To our knowledge, we report the first case of NL-FHN associated with systemic juvenile idiopathic arthritis. Interestingly, despite the poor prognosis of NL-FHN reported in the literature, we observed a complete renal response after early identification and subsequent tocilizumab regimen tailored by clinical manifestations and disease activity. This observation highlights the importance of early diagnosis and the potential link between underlying autoimmune disease and the development of NL-FHN in some patients.

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