par Siminska-Stanny, Julia 
;Noirot, Isaline I.N;Marcotulli, Martina M.M;Nair, Malavika M.N;Carugo, Dario D.C;Shavandi, Armin ;Stride, Eleanor E.S
Référence TERMIS 2026(20-24 April: Spain, Palma de Mallorca), Volumetric printing of porous constructs for studying enhanced transport and targeted drug delivery in vascularized tissue models
Publication Publié, 2026-04-21
;Noirot, Isaline I.N;Marcotulli, Martina M.M;Nair, Malavika M.N;Carugo, Dario D.C;Shavandi, Armin ;Stride, Eleanor E.SRéférence TERMIS 2026(20-24 April: Spain, Palma de Mallorca), Volumetric printing of porous constructs for studying enhanced transport and targeted drug delivery in vascularized tissue models
Publication Publié, 2026-04-21
Abstract de conférence
| Résumé : | Ultrasound and cavitation mediated drug delivery has great potential but in vitro models relying onconventional hydrogels poorly mimic biological tissue. Using volumetric 3D printing, we createdperfusable constructs with controlled pore organization and assessed their ability to mimic tissue in termsof the diffusion and ultrasound-mediated transport of drug molecules. Compared to bulk hydrogels, newporous constructs had lower stiffness and improved fluid redistribution, sustaining cavitation underperfusion without failure at tested pressures. Transport studies demonstrate more biomimetic penetrationand distribution in interconnected pore networks.These findings support the use of porous, perfusable hydrogels as tunable platforms for studyingultrasound-mediated transport under controlled mechanical and flow conditions. |
