par Gonze, Didier
Référence Current opinion in systems biology, 44, page (100580)
Publication Publié, 2026-03-20
Article révisé par les pairs
Résumé : The generation of robust circadian oscillations in the suprachiasmatic nucleus relies on intercellular coupling and synchronization of cell-autonomous clocks. When uncoupled, individual cells display considerable heterogeneity in amplitude and period, and a large fraction of cells undergo damped oscillations. We review here modeling approaches and summarize theoretical findings regarding synchronization mechanisms and entrainment properties of the multi-cellular circadian network. We also discuss recent experimental efforts aiming to characterize the synchronization dynamics.

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