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Natural Therapeutics Against Prostate Disorders in Guinea: An Ethnobotanical Survey and Biological Activities of Some Medicinal Plants

par Bah, Tanou Valdez Bah TV;Megalizzi, Véronique ;Diané, Séré;Diallo, Mamadou Saliou Telly;Camara, Mohamed ;Oularé, Ansoumane;Tietjen, Ian;Baldé, Elhadj Saïdou
Référence Tropical Journal of Natural Product Research, 9, 10, page (4868-4878)
Publication Publié, 2025-10

Article révisé par les pairs

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Résumé :

Limited access to healthcare has led many Guineans, particularly in rural areas, to rely on medicinal plants to treat health issues, including prostate disorders. This study aimed to collect information on medicinal plants traditionally used in Guinea to manage prostate diseases and investigate their in vitro antioxidant and anti-inflammatory activities. An ethnobotanical investigation was conducted in three Guinean regions, where 277 traditional healers were interviewed and medicinal plants were collected for study. A total of 55 plant species belonging to 29 botanical families were identified. Fifteen plant species were evaluated for their antioxidant and anti-inflammatory activities. Among the 15 plants tested, the highest polyphenol content was found in the methanol extract of Alchornea cordifolia (335.7 ± 19.3 mg EAG/g extract). Promising antioxidant activity, including the ability to scavenge free radicals and reduce metal ions, was observed in Khaya senegalensis A.Juss. and Alchornea cordifolia (Schumach.). Müll.Arg., and Anonychium africanum (Guill. & Perr.), at a concentration of 500 µg/mL. The highest anti-inflammatory activity was exhibited by Azadirachta indica A.Juss., Paullinia pinnata (L.), Tamarindus indica L., and Milicia excelsa (Welw.) C.C.Berg, and Harungana madagascariensis Lam. Ex Poir. with IC50 ≥50%. This study provides a comprehensive overview of the medicinal plants used by Guinean traditional healers in the management of prostate diseases. Several plant species have also demonstrated significant antioxidant and anti-inflammatory activities, suggesting their potential as sources for developing new therapeutic leads to target non-communicable diseases, such as cancer.