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Physicochemical and rheological characterization of new local excipient powders as adjuvant for oral formulations

par Guilao, Mory Guilao M;Wauthoz, Nathalie ;Bah, Tanou Valdez Bah TV;Atchade, Constantin;Traoré, Tata;Souard, Florence ;Sombie, Charles Bavouma;Semde, Rasmané ;Balde, Elhadj Saïdou
Référence 22 nd Forum Belgian Society of Pharmaceutical Sciences(31 mars 2025: Floreal, la Roche-en-Ardenne)
Publication Publié, 2025-06-15

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PHYSICOCHEMICAL AND RHEOLOGICAL CHARACTERIZATION OF NEW LOCAL EXCIPIENT POWDERS AS ADJUVANT FOR ORAL FORMULATIONSGuilao M 1,2,3, Wauthoz N 3, Bah TV 1,2, Atchade C4, Traore T 4, Souard F 3, Sombié C 5, Semdé R 5, Baldé ES 1,2 1 Département Sciences Pharmaceutiques et biologiques, FSTS, Gamal Abdel Nasser University of Conakry (UGANC), Conakry, Guinea Republic2 Institute of Research and Development of Medicinal and Food Plants of Guinea Dubréka, Guinea Republic.3 Department of Pharmacotherapy and Pharmaceutics, Faculty of Pharmacy, Université libre de Bruxelles, Ixelles, Belgium4 Institute of Research in Health Sciences, Ouagadougou, Burkina Faso 5 Joseph Ki Zerbo University of Burkina Faso, Ouagadougou, Burkina FasoIntroduction: The medicinal plant industry holds great potential in the quest to transform health systems and economies in sub-Saharan Africa 1. Developing new local excipients from renewable and sustainable natural resources is required to increase the ability of Guinea to develop its own medicinal products. The objective of this study is to characterize and evaluate the ability of new excipients that could serve as effective adjuvant for oral formulation of medicinal products. Materials and Methods: Manihot esculenta, Zea mays, Combretum glutinosum, Englerina lecardii, rice bran and acacia gum were the renewable and sustainable natural material. We carried out an aqueous extraction with water and ethanol, acetone solvents in cold and hot conditions to obtain starches (from cassava; corn,), fibers (from rice bran) and cellulose (from Combretum glutinosum, Englerina lecardii). The physicochemical characterization (pH, aqueous solubility, residual humidity, hygroscopicity, viscosity and granulometry by sieves) are performed. The flowability was evaluated by determining angle of repose, Hausner index, and Carr’s Index3Results and Discussion: Table 1: Extraction and main physicochemical properties of excipients powdersExcipients Extraction yield (%) Residual moisture (%) Aqueous solubility (g/ml) Hygroscopicity (%) Sulfuric ashes ( %)Cassava starch 24,80 8,50 1/1000 - 1,98Corn starch 27,02 7,17 1/1000 - 2,11Rice bran starch 20,50 5,24 1/1000 15,90 2,1Rice bran fiber 69 3,83 > 10 000 6,10 2,26Cellulose 43,66 5,67 1/1000 3,60 2,11Acacia gum - 3,00 1/30 3,80 2,15Table 2: Particle size and flowability of excipient powders Excipient Particle size (D50 mm) Carr’index % Hausner index Angle of reposeCassava starch 0,386 19 1,25 34,85Corn starch 0,230 20 1,25 33,91Rice bran fiber 0,366 21,33 1,27 45,14Acacia gum 0,380 13 1,15 33,68Dispersion of 30% m/v of Acacia gum (50 mPa.s) was less viscosity than cassava starch (720 mPa.s) and corn starch (700 mPa.s). Data on the flowability of powders (acacia gum, cassava and corn starches) from Table 2, could be a factor promoting granulation.Conclusion: These preliminary results will allow specific tests to be initiated with acacia gum and starch of cassava and corn to evaluate the binding properties in the oral formulation of granules and their dissolution.References1Ouedraogo S et al. Production of raw materials and manufacture of herbal medicines. Int J Biol Chem Sci. Jun 23, 2021 ;15(2) :750-72. 2European Pharmacopoeia 10th Edition. 3Mory G et al. Production and characterization of cassava and maize starch of the manufacturing of improved traditional medicines. Guinee med. 2023, 107(3) 143-148.