par Van Keymeulen, Alexandra ;Roger, Pierre P. ;Dumont, Jacques Emile ;Dremier, Sarah
Référence Biochemical and Biophysical Research Communications, 273, 1, page (154-158)
Publication Publié, 2000
Article révisé par les pairs
Résumé : Ras activation by receptor tyrosine kinases or serpentine receptors is generally considered to be essential for G1 phase progression and mitogenesis. In the physiologically relevant model of primary dog thyrocytes, the accumulation of the GTP-bound form of Ras constituted an early convergence point of various mitogenic or comitogenic stimuli including EGF, HGF, phorbol esters, insulin and carbachol. By contrast, the basal level of GTP-Ras was slightly reduced by TSH and forskolin and did not increase during the TSH/cAMP-dependent progression into G1 phase. This rules out a role for the activation of Ras as a signal in the mitogenesis elicited by TSH via cAMP in these cells.