Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

Muralidharan, Charanya; Huang, Fei; Enriquez, Jacob J.R.; Wang, Jiayi J.E.; Nelson, Jennifer J.B.; Nargis, Titli; May, Sarah S.C.; Chakraborty, Advaita; Figatner, Kayla K.T.; Navitskaya, Svetlana; Anderson, Cara C.M.; Calvo, Veronica; Surguladze, David; Mulvihill, Mark M.J.; Yi, Xiaoyan; Sarkar, Soumyadeep; Oakes, Scott S.A.; Webb-Robertson, Bobbie Jo B.J.M.; Sims, Emily EK; Staschke, Kirk K.A.; Eizirik, Decio L.; Nakayasu, Ernesto Satoshi; Stokes, Michael M.E.; Tersey, Sarah SA; Mirmira, Raghavendra R.G.

doi:doi/10.1172/JCI176136

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Disclosures: VC, MES, DS, and MJM are employees of HiberCell, Inc. SAT, RGM, and HiberCell have filed a provisional patent on compounds to inhibit PERK in type 1 diabetes. SAT and RGM received an investigator-initiated award from HiberCell, Inc. for use of PERK inhibitors in this study. KAS is a consultant for and has received research support from HiberCell, Inc. SAO is a co-founder, equity holder, and consultant for OptiKIRA, LLC.

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