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Malignant phyllodes tumor of the breast: A practice review

par Fêde, Ângelo;Souza, Ronaldo Pereira;Doi, Mauricio;De Brot, Marina;Osorio, Cynthia Aparecida Bueno de Toledo C.A.B.d.T.;Gondim, Guilherme Rocha Melo;Casali-Da-rocha, Jose Claudio;Jbili, Rima;Bitencourt, Almir Galvao Vieira;de Souza, Juliana Alves;Caparica Bitton, Rafael ;Makdissi, Fabiana Baroni Alves;Sanches, Solange Moraes
Référence Clinics and Practice, 11, 2, page (205-215)
Publication Publié, 2021

Article révisé par les pairs

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Résumé :

Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy. Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor. Conclusions: mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors.