par Azim, Hamdy Abdel Bdel H.A.;Nguyen, Bastien 
;Abdel Azim, Hatem Hamdy
Référence Breast Cancer in Young Women, Springer International Publishing, page (13-22)
Publication Publié, 2020-01
;Abdel Azim, Hatem Hamdy Référence Breast Cancer in Young Women, Springer International Publishing, page (13-22)
Publication Publié, 2020-01
Partie d'ouvrage collectif
| Résumé : | Several studies have shown that breast cancer arising at young age is associated with worse prognosis. Mounting evidence suggests that they are enriched with more aggressive breast cancer subtypes, notably triple-negative or basal-like tumors. However, this does not appear to explain fully the worse outcomes observed in these patients. Recent studies have also pointed out that outcomes are particularly poorer in patients with estrogen receptor-positive tumors underscoring the potential impact of the endocrine microenvironment, which is predominantly different in young patients, on the biology and nature of these tumors. In this chapter, we discuss key major biological aberrations that characterize breast cancer that arises at young age and their potential clinical implications. |
