par Abdel Azim, Hatem Hamdy 
;Fumagalli, Debora ;Sotiriou, Christos
Référence Handbook of Metastatic Breast Cancer, Second Edition, CRC Press, page (4-12)
Publication Publié, 2014-01
;Fumagalli, Debora ;Sotiriou, Christos Référence Handbook of Metastatic Breast Cancer, Second Edition, CRC Press, page (4-12)
Publication Publié, 2014-01
Partie d'ouvrage collectif
| Résumé : | INTRODUCTION Gene-expression profiling with the use of DNA microarray allows measurement of thousands of messenger RNA transcripts in a single experiment. Results of such studies have confirmed that breast cancer (BC) is not a single disease, but rather a group of molecularly distinct subtypes ( 1 ). In this regard, four main molecular classes of BC have been identified which are as follows ( 2 – 5 ): luminal-A cancer, which is mostly low proliferative oestrogen receptor (ER) positive; luminal-B, which is mostly high proliferative ER positive; basal-like cancer, which is negative for ER, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) and finally HER2-positive cancer which is characterised by the amplifi cation of the HER2 gene. |
