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Hollow-adjustable polymer microneedles for prolonged hypoglycemic effect on diabetic rats

par Liu, Tianqi;Sun, Yanfang;Zhang, Wenjing;Wang, Rui;Lv, Xinyu;Nie, Lei ;Shavandi, Armin ;Yunusov, Khaydar;Jiang, Guohua
Référence Chemical engineering journal, 481, page (148670)
Publication Publié, 2024-02-01

Article révisé par les pairs

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Résumé :

Maintaining blood glucose levels within a safe range is critical for diabetic management. In recent decades, microneedles (MNs) have emerged as a potential method for delivering drugs to treat diabetes. However, insufficient drug loading and the complexity of achieving long-acting release have presented challenges that research has not addressed well. In this study, the hollow-adjustable biocompatible polymer MNs with varying cavity volumes were developed by cyclic freeze-thawing technique. The structure of shell-layer of hollow MNs was optimized with a sequential casting approach for regulating drug release kinetics. This design can ensure the sufficient mechanical strength of MNs and help to improve the drug-loading capacity, thereby solving the problem of low drug-loading capacity and short pharmacodynamic action time of traditional polymer MNs. In vivo experiments performed on diabetic rat models revealed the potential of the as-fabricated MNs to effectively pierce into the skin, leading to a notable hypoglycemic effect lasting up to 14 h without inducing the risk of hypoglycemia. These results indicate that the fabricated hollow-adjustable polymer MNs is a potential candidate for transdermal delivery of high-dose drugs.