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Acute myeloid leukemia-derived exosomes deliver miR-24-3p to hinder the T-cell immune response through DENN/MADD targeting in the NF-κB signaling pathways.

par Otmani, Khalid ;Rouas, Redouane ;Lagneaux, Laurence ;Krayem, Mohammad ;Duvillier, Hugues ;Berehab, Mimoune ;Lewalle, Philippe
Référence Cell Communication and Signaling, 21, 1, page (253)
Publication Publié, 2023-09-01

Article révisé par les pairs

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Résumé :

microRNAs (miRNAs) are known as potent gene expression regulators, and several studies have revealed the prognostic value of miRNAs in acute myeloid leukemia (AML) patient survival. Recently, strong evidence has indicated that miRNAs can be transported by exosomes (EXOs) from cancer cells to recipient immune microenvironment (IME) cells.