• Citer

Copper-Catalyzed Cross-Coupling of Acylzirconocenes and Diaryliodonium Salts: An Efficient Synthesis of Alkyl-aryl-ketones from Alkenes

par Grosso, Simone ;Mlynczak, Marcelina;Evano, Gwilherm ;Riant, Olivier
Référence European Journal of Organic Chemistry, e202300938
Publication Publié, 2023-10-30

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

An efficient and unprecedented cross-coupling between acylzirconocenes, readily available starting materials conveniently prepared by hydrozirconation of alkenes and a subsequent carbonylation with carbon monoxide, and diaryliodonium tetrafluoroborates is reported. This procedure enables the synthesis of a broad variety of alkyl-aryl-ketones upon simple catalysis with copper cyanide without the need of additional ligands and only requires a low pressure of carbon monoxide generated in situ, in a two-chamber reactor, from N-formylsaccharin.