par Dube, Gaurav 
;Tiamiou, Assia;Bizet, Martin ;Boumahd, Yasmine;Gasmi, Imène;Crake, Rebekah;Bellier, Justine;Nokin, Marie Julie;Calonne, Emilie ;Deplus, Rachel ;Wissocq, Tom;Peulen, Olivier;Castronovo, Vincent;Fuks, François ;Bellahcène, Akeila
Référence Journal of experimental & clinical cancer research : CR, 42, 1, page (78)
Publication Publié, 2023-03
;Tiamiou, Assia;Bizet, Martin ;Boumahd, Yasmine;Gasmi, Imène;Crake, Rebekah;Bellier, Justine;Nokin, Marie Julie;Calonne, Emilie ;Deplus, Rachel ;Wissocq, Tom;Peulen, Olivier;Castronovo, Vincent;Fuks, François ;Bellahcène, AkeilaRéférence Journal of experimental & clinical cancer research : CR, 42, 1, page (78)
Publication Publié, 2023-03
Article révisé par les pairs
| Résumé : | Aerobic glycolysis, also known as the Warburg effect, is predominantly upregulated in a variety of solid tumors, including breast cancer. We have previously reported that methylglyoxal (MG), a very reactive by-product of glycolysis, unexpectedly enhanced the metastatic potential in triple negative breast cancer (TNBC) cells. MG and MG-derived glycation products have been associated with various diseases, such as diabetes, neurodegenerative disorders, and cancer. Glyoxalase 1 (GLO1) exerts an anti-glycation defense by detoxifying MG to D-lactate. |
