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Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.

par McLaughlin, Kerry;Acreman, Samuel;Nawaz, Sameena;Cutteridge, Joseph;Clark, Anne;Knudsen, Jakob G;Denwood, Geoffrey;Spigelman, Aliya AF;Manning Fox, Jocelyn JE;Singh, Sumeet Pal ;MacDonald, Patrick E;Hastoy, Benoit;Zhang, Quan
Référence Diabetic medicine, 39, 12, page (e14984)
Publication Publié, 2022-12-01

Article révisé par les pairs

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Résumé :

Tetraspanin-7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate β-cell L-type Ca2+ channel activity. However, the role of Tspan7 in pancreatic β-cell function is not yet fully understood.